image from IGSB
Updated June 30, 2015

CBC funded Awards

The CBC seeks to stimulate collaboration among scientists at Northwestern University, the University of Chicago, and the University of Illinois at Chicago that will transform research at the frontiers of biomedicine. CBC funding opportunities have enabled our three member institutions to create a novel and innovative collaborative effort, linking researchers, resources, and facilities to enable fundamental breakthroughs in scientific understanding. Catalyst, Spark and Lever RFAs welcome broad participation among scientists at our three member institutions. To learn more about previous awards, please visit the links below.



» 2014 Fall Round
» 2014 Spring Round



» 2014 Spring Round
» 2013 Fall Round
» 2013 Spring Round



2014 Fall Round
» Mapping the Regulation of Wnt Signaling with β-Cat-eleon: A Fluorescent β-catenin “timer”
» Role of Dynamics in the Structure and Function of Intrinsically Metastable Proteins
» Photoaffinity-based Protein Profiling Approach to Discover Estrogen Receptor/ Coactivator Inhibitors
» Label-free Chemical Imaging: Early Detection of Heart Transplant Rejection
» Nuclear Opening and Histone Release in Mammalian Terminal Erythropoiesis
» Co-occurance and Implications of Antibiotic Production and Resistance Genes in the Environment

2014 Spring Round
» Uncovering 'Missing Heritability' in Any Experimentally Tractable Model Organism
» Control of Hematopoietic Stem Cell Expansion by Inhibition of Axin Polymerization
» Development of a 3D Snapshot Holographic Microscope for Volumetric Live Cell Imaging
» Klebsiella Pneumoniae Pathogenesis in Immunocompetent and Immunosuppressed Hosts

2013 Fall Round
» Craniofacial Tissue Engineering with Citric-Acid Based Nanocomposite Scaffolds
» Extra-translational Function of Transfer RNA as Regulators of Cellular Processes
» Structural Basis for RecA Filament Nucleation by the Neisseria PilE G Quadruplex Motif
» Probing Somatosensory Representations in the Brainstem of Awake Monkeys
» Immunotherapy-Mediated Interference of Bacterial Quorum Sensing
» ApoA-I Mediated Regulation of Inflammation and Heart Repair after Heart Attack

2013 Spring Round
» Radiation-guided delivery of quantum dot theranostic nanoparticles
» An “And-Gate” for Optogenetic Control Of Protein Kinases
» Engineering Prokaryotic Translation for Artificial Metalloenzyme Production
» A Novel Antimicrobial Strategy Against Methicillin-Resistant S Aureus (MRSA)
» Characterizing in Vivo Chromatin Folding Landscape of IgH locus on Chromosome 12
» Identifying Immune Evasion Mechanisms in Tumors Via a Genome-Wide shRNA Screen

2012 Fall Round
» Proteomic Characterization of Epicardial-Myocardial Signaling and Regenerative Activity
» Dissecting cis versus trans regulation of gene expression using in vitro transcription
» Nuclear Actin and Genome Organization

2012 Spring Round
» Development of novel affinity reagents to monitor different activation states of Ras GTPases in cells
» Common bone marrow homing pathways for HSC and SCLC stem cells
» Genome Wide siRNA Screen for Host Factors Required for Human Herpesvirus (HHV) Latency
» Genome-scale identification of protein docking interactions

2011 Fall Round
» Design and Delivery of TAT Fusion Proteins for CPR
» Capturing Kinetically Labile Protein Assemblies on DNA
» Oxygen Sensing in Endothelial Progenitor Cells
» A Molecular Chart Recorder

2011 Spring Round
» Identify Cell Cycle-Regulatory Substrates Ubiquitinated by the Apoptosis Inhibitor BRUCE
» An approach to identify drug targets that select against antibiotic resistance

2010 Fall Round
» Uncovering Early Genetic Aberrations in Myelodysplastic Syndromes
» The Molecular Basis of Genomic Instability: A Genome Wide Approach

2010 Spring Round
» In situ Imaging of Lipid Signaling Networks
» Critical Components in Regulated Secretion
» Phosphoproteomic analysis of NADPH oxidase activation

2009 Fall Round
» High throughput signaling pathway analysis during cellular organization into structures
» A Systems Biology Understanding of Estrogen Receptor Action
» Cell Cycle Regulatory Networks: An Integrative Approach

2009 Spring Round
» Genetically Encoded Control of Protein Function with Light
» New Molecular Tools to Study Cancer Metabolic Reprogramming
» Virulence and Latency Regulation in M. tuberculosis

2008 Fall Round
» Proteolysis-inducing Peptides as Tools for Chemical Genetics

» Investigating the in vivo Interactomes of BACE1 and APP

2008 Spring Round
» Testing the ‘Occlusis’ Model of Cell Fate Restriction

2007 Fall Round
» Gene Regulatory Networks Directing Hematopoietic Cellular Fates
» Multiplexed Imaging of Transient Molecular Complex Dynamics in vivo
» Proteomic Analysis of Mitochondrial and Sarcomeric Proteins in Cardiomyopathy
» Spatiotemporal Dynamics of Cellular Protein Networks on Membranes

2007 Spring Round
» Gene Regulation by Natural Antisense RNAs in Yeast
» Chicago Consortium in Diabetes and Obesity Genetics

2006 Fall Round
» Systems Analysis of Chromosome Dynamics in Single Bacteria

2006 Spring Round
» Advanced System for Comparative Analysis of Metabolism
» Epigenetics of RNA: a systems approach
» Viral Vector Translational Resource Center
» Functions and Evolution of micro-RNAs

(back to the top)



Spark Award Program ran from 2008 until August 2011. The Program focused on mid-sized collaborative projects of exceptional creativity. Past CBC Spark Awards are listed below:

August 2011
Leptin peptide in diabetes: from mechanism to therapeutics

September 2009
Delivery of synthetic antibodies to probe cell dynamics in live cells

June 2009
Support for An Innovative CryoSTEM for Element Specific Imaging of Cells and Tissue

March 2009
The Role of Natural Variation and Proteostasis in Complex Disease Traits

January 2009
Noncoding RNA Structure, Function, and Evolution

January 2009
Metabolic MR Imaging for Studies of Human Brain Disease

November 2008
The Chicago Laminome Project

(back to the top)



May 2015
Chicago Center for Physical Science-Oncology Innovation and Translation

May 2012
Center for Production of Affinity Reagents for Human Transcription Factors: Chicago Synthetic Antibody Pipeline

May 2012
Silvio O. Conte Center on the Computational Systems Genomics of Psychiatric Disorders

October 2010
Nanomaterials for Cancer Diagnostics and Therapeutics

January 2009
Chicago Tri-Institutional Center of Excellence in Chemical Methodologies & Library Development

July 2008
Chicago Center for Systems Biology


(back to the top)