Poster Details

Poster # 8

STRUCTURAL BIOLOGY FACILITY OF NORTHWESTERN UNIVERSITY

Authors: Alfonso Mondragon, Faculty Director; Valerie Tokars, Operations Director; Jason Pattie, Computational Facility Manager; Pamela J Focia, Facility Manager, Structural Biology Facility, Northwestern University


PRESENTER’S INFO:
Name: Pamela Focia
Email: focia@northwestern.edu
Title: Faculty
Affiliation: Northwestern University
Department: Structural Biology Facility
Advisor: Valerie Tokars
Advisor’s Email: v-tokars@northwestern.edu


Abstract: The primary mission of the Structural Biology Facility is to provide state-of the-art instrumentation, training, technical support, and maintenance of equipment indispensable for structural biologists and other researchers studying the structures of biological macromolecules and biomaterials as well as full structure determination services for researchers seeking structural information. The Facility plays an essential role in the research programs of investigators who are studying the relationship between macromolecular structure and function, using macromolecular structure as the starting point for structure-based drug design, or needing to characterize complex biomaterials. It provides regular access and support for experiments using the synchrotron radiation X-ray source at the Life Sciences Collaborative Access Team (LS-CAT) beamlines at the Advanced Photon Source (APS) at Argonne National Laboratory, and state-of-the-art electron microscopes and detectors, suitable for atomic-level structural studies by cryo-Electron Microscopy (CryoEM) located in the Evanston campus. In addition, the Facility provides crystallization robotics, crystal manipulation and analysis tools, and computational resources for analyzing data produced by a wide range of experimental approaches together with computational tools for modeling and design studies. Finally, the Facility also provides full structure determination services for research groups in need of structural studies support for their research.


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