Updated: February 19, 2013
CBC Scholar: Class of 2010
Department of Bioengineering and Center for Pharmaceutical Biotechnology, UIC, Advisor: Michael Johnson
JOHNSON LAB WEBPAGE
Rima successfully defended her thesis work in December 2010. Her dissertation was titled: "Drug Discovery and Design for the inhibition SARS-Coronavirus and Hepatitis C virus."
Research Officer at the Garvan Institute for Medical Research in Sydney, Australia.
Rima is working in the Diabetes and Obesity program in the lab of Professor David E. James as a system biologist / bioinformatician.
JAMES LAB WEBPAGE
Institute of Research for Biomedicine, University of Barcelona at the Barcelona Science Park, Spain
Postdoctoral Researcher, PI: Modesto Orozco, Ph.D.
2010 – 2012
University of Illinois at Chicago
2005 – 2010
Georgia College & State University
BA, Magna cum Laude, Major in Management of Information Systems (MIS), minor in Computer Science,
2000 – 2004
Chaudhuri R, Carrillo O, Laughton CA, Orozco M. Application of Drug-Perturbed Essential Dynamics/Molecular Dynamics (ED/MD) to Virtual Screening and Rational Drug Design. J. Chem. Theory Comput. 2012 8 (7): 2204–2214. (ACS Publications)
Chaudhuri R, Lee H, Truong L, Torres J, Patel KK, Johnson ME. Identification of Non-Macrocyclic Small Molecule Inhibitors against the NS3/4A Serine Protease of Hepatitis C Virus through In-silico Screening. J Chem Inf Model. 2012 Aug 27;52(8):2245-56. (PubMed)
Lee H, Torres J, Truong L, Chaudhuri R, Mittal A, Johnson ME. Reducing agents affect inhibitory activities of compounds: Results from multiple drug targets. Anal Biochem. 2012 Jan 18;423(1):46-53. (PubMed)
Chaudhuri R, Tang S, Zhao G, Lu H, Case DA, Johnson ME. Comparison of SARS and NL63 Papain-Like Protease Binding Sites and Binding Site Dynamics: Inhibitor Design Implications. J Mol Biol. 2011 Nov 25;414(2):272-88. (PubMed)
Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. J Med Chem. 2010 Jul 8;53(13):4968-79. (PubMed)
Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. J Med Chem. 2009 Aug 27;52(16):5228-40. (PubMed)
Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24. (PubMed)
AWARDS, HONORS AND OFFICES HELD:
- CBC Scholar, 2010
- Travel award to the Keystone Symposium, Whistler, Canada, 2010
- Honorable mention, University of Illinois Graduate Research Forum, 2009
- 1st place, University of Illinois Graduate Research Forum, 2007
- Scientific Research Society: Sigma Xi