Meet the Scholars

Updated: June 12, 2015

Sam Nalle

Sam Nalle

CBC Scholar: Class of 2010
Department of Pathology (BSD), UChicago, advisor: Jerrold Turner

Current position: Postdoctoral Fellow, Genentech



University of Chicago
Ph.D., Molecular Pathogenesis and Molecular Medicine
2006 – 2011

Macalester College
B.A., Biology
2002 – 2005



Transplantation, alloreactivity, graft-versus-host disease, antigen presentation, epithelial cell biology, mucosal immunology.



Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. Review. Mucosal Immunol. 2015 May 6. [Epub ahead of print] (PubMed)

Nalle SC, Aimee Kwak H, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, Turner JR. Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Sci Transl Med. 2014 Jul 2;6(243):243ra87. (PubMed)

Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis. Gastroenterology. 2013 Aug;145(2):407-15. (PubMed)

Nalle SC, Turner JR. Endothelial and epithelial barriers in graft-versus-host disease. In: Biology and Regulation of Blood-Tissue Barriers. Ed: C. Yan Cheng. Landes Biosciences. 2012. (Landes Bioscience)

Nalle SC, Turner JR. Menetrier’s disease therapy: Rebooting mucosal signaling. Science Translational Medicine 2009;1:8-10. (Sci Transl Med)

Nalle SC, Turner JR. Epithelium, tear down this wall! Cell Host Microbe 2009;5:1-2. (PubMed)

Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 2009;136:551-63. (PubMed)

Weber CR, Nalle SC*, Tretiakova M, Rubin DT, Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest 2008;88:1110-20. *co-first author (PubMed)

Nalle SC. ROCKing the matrix. Laboratory Investigation. 2007. 87:1068-1069. (Laboratory Investigation)



Best Dissertation Award – Molecular Pathogenesis and Molecular Medicine Graduate Program. 2011.

Takeda Travel Award for Experimental Biology 2011 – based on competitive ranking of submitted abstracts. Washington, D.C. 2011.

Travel Award for American Society of Hematology Annual Meeting – based on competitive ranking of submitted abstracts. Orlando, FL. 2010.

Chicago Biomedical Consortium Scholar. 2010-2011.

Crohn’s and Colitis Foundation of America Travel Scholarship – to finance attendance at the Microbes and Mucosal Immunity Course at the University of Virginia. June, 2008.