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October 18, 2017

Local expert and twice CBC awardee, Ravi Allada (NU), explains the circadian rhythm on Chicago Tonight

The announcement of the Nobel Prize in Physiology or Medicine awarded to three American circadian rhythm researchers, Jeffrey C. Hall, Michael Rosbash and Michael W. Young, prompted Chicago Tonight to approach Ravi Allada for comments. Allada is a Northwestern University expert on the internal clocks and twice a CBC awardee for research related to the circadian rhythm. In 2015, an Allada lab postdoc, Dae-Sung Hwangbo, was awarded a CBC Postdoctoral Research Award to study a circadian metabolome. The following year, Allada, together with UChicago circadian rhythm expert, Michael Rust, received a CBC Catalyst Award for the project: “Transplanting a Prokaryotic Oscillator to Animals to Restore Circadian Clock Function.”

Northwestern Professor Asks, ‘What Makes Our Internal Clocks Tick?’

Our circadian rhythm is driven by a 24-hour internal clock that responds to changes in the environment, such as the sunrise or a drop in the outside temperature.

Whether you’re a night owl or an early bird, this internal clock determines when you rest and rise.

“Basically, the circadian clock acts like an internal alarm clock,” said Ravi Allada, a professor and chair of the Department of Neurobiology at Northwestern University. “That alarm clock inside your body goes off and it basically wakes you up at the same time every day.”

This biological clock is found in many types of animals, plants and even fungi. Along with human sleep cycles, it determines the release of hormones, regulation of body temperature and other important bodily functions.

Last week the Nobel Prize in Physiology or Medicine was awarded to three American scientists, Jeffrey C. Hall, Michael Rosbash and Michael W. Young, for their circadian rhythm research.

Using fruit flies as a model, the three identified a specific gene that regulates the insect’s internal clock. This function was later observed in humans. In fact, virtually all life on Earth is coordinated to some sort of 24-hour rhythm in sync with the Earth’s rotation.

Allada said the Nobel Prize winners’ research, published in 1984, helped us better understand how that clock works. “We didn’t know the gears of these internal circadian clocks,” Allada said. “They discovered some of the key components, or gears, of the circadian clock.”

Allada joins us to discuss this breakthrough research and other sleep-related studies.


Adapted (with modifications) from Chicago Tonight, originally posted by Evan Garcia on October 10, 2017.

See also:

CBC Catalyst Award (2016):
PIs: Michael Rust (UChicago) and Ravi Allada (NU) for the project:
▸ Transplanting a Prokaryotic Oscillator to Animals to Restore Circadian Clock Function

CBC Postdoctoral Research Award (2015):
PIs: Dae-Sung Hwangbo and Ravi Allada (NU) for the project:
▸ The Circadian Metabolome : Broker of Sleep and Diet Effects on Lifespan and Aging