June 13, 2019 | Jola Glotzer
Oogenesis — what could possibly go wrong?
In a recent review published in Current Opinion in Cell Biology, Sadie Wignall, Associate Professor at NU and CBC Junior Investigator, discusses oocyte meiosis
Congratulations to Sadie Wignall, NU, on her recent publication in Current Opinion in Cell Biology, titled “Spindle assembly and chromosome dynamics during oocyte meiosis.” The review discusses oogenesis — the process of oocyte development — through the meiotic cell division. Using C. elegans as an experimental model system, Sadie discusses the role of the cytoskeleton in assuring proper chromosome segregation into the haploid oocytes, as well as the types of abnormalities that tend to occur during meiosis that lead to a high percentage of defective oocytes observed in nature.
Sadie is a CBC Junior Investigator — she was hired by NU in 2011 with help from a generous CBC Recruitment Resources Award, issued to outstanding young candidates with demonstrated records of excellence who were entering their first faculty positions as tenure-track assistant professors. In addition, Sadie was later a recipient of a CBC Catalyst Award in 2016 for a project: “Spatial and Temporal Dissection of Mouse Meiotic Chromosome Segregation.” Sadie has since served on the CBC Catalyst Review Board (2017). CBC is grateful for her service and wishes her continued success in her scientific endeavors.
Publication linked to CBC funding*:
Mullen TJ, Davis-Roca AC, Wignall SM. Spindle assembly and chromosome dynamics during oocyte meiosis. Curr Opin Cell Biol. 2019 May 10;60:53-59. [Epub ahead of print] Review. (PubMed)
Organisms that reproduce sexually utilize a specialized form of cell division called meiosis to reduce their chromosome number by half to generate haploid gametes. Meiosis in females is especially error-prone, and this vulnerability has a profound impact on human health: it is estimated that 10–25% of human embryos are chromosomally abnormal, and the vast majority of these defects arise from problems with the female reproductive cells (oocytes). Here, we highlight recent studies that explore how these important cells divide. Although we focus on work in the model organism Caenorhabditis elegans, we also discuss complementary studies in other organisms that together provide new insights into this crucial form of cell division.
Featured CBC Community member(s):
ARTICLES PUBLISHED IN THE PAST ABOUT THE FEATURED CBC COMMUNITY MEMBER(S):
May 14, 2019
▸ Kif4’s role in acentriolar oocytes
CBC Junior Investigator, Sadie Wignall, NU, examines the progression of meiosis in live mouse oocytes despite lack of centrioles
May 22, 2018
▸ “Oligometastasis,” or a cancer that has metastasized but just to a few sites, not globally, is still treatable. CBC Senior Investigator, Kevin White, UChicago, contributes to the discovery.