“In the News”

August 17, 2020   I   Jola Glotzer

Supporting Chicago-centered entrepreneurialism

CBC Accelerator Award to Arnon Lavie, UIC, among early innovation grants that got a UIC spinoff company, Enzyme by Design, to a flying start

Enzyme by Design – a startup founded by CBC Awardee Aaron Lavie, UIC.

Arnon Lavie, PhD, UIC, first pitched his translational idea to the CBC in early 2018 when he submitted a Letter of Intent for the inaugural round of the CBC Accelerator Award applications. Following a successful presentation of his proposal to the CBC Accelerator Award Review Board, Lavie was invited to submit a complete application and in May 2018, he was announced as one of five winners of the CBC Accelerator Award, for the project: “Increasing the in vivo Stability of L-asparaginase through Interactions with HSA.”

The CBC Accelerator Award program aims to support translational research and provide university researchers with “early commercial guidance.” Accelerator Awards are designed to support the initial, and therefore highest risk, stage of commercially-directed research focused on the development of a therapeutic or an associated biomarker or diagnostic. The awards are up to $100,000 with a possibility of a renewal for an additional $150,000 for the second year.

Lavie’s idea has materialized, and now he is the founder and CEO of the startup company Enzyme by Design. The company’s goal is to introduce to the market a new form of asparginase — an enzyme used to treat acute lymphoblastic leukemia. Enzyme by Design’s asparginase is as potent as the currently used form of the enzyme, however, unlike the toxic and even lethal sides effects of the current form, it has potentially no toxicity at all.

Below, we have posted a recent interview with Dr. Lavie, for the Illinois Ventures, that touches on important steps that are needed to make a startup a success. Quoting from the article, “It will take a group effort of diverse researchers, industry partners, and funders to map out the future of Illinois’ innovation ecosystem.”

The CBC is proud to have contributed by providing support to Dr. Lavie at this critical point of his company formation.

July 29, 2020  |  Illinois Ventures

Coffee with a Founder: Arnon Lavie of Enzyme by Design

When it comes to creating a successful startup, innovation funds combined with ecosystem mentorship are key to guiding valuable academic research to commercialization. The process of creating a company and seeking grants is complex. It’s not rocket science, but for bona fide rocket scientists, therapeutic researchers, and academic innovators, this part of the process is outside their area of expertise. Specialized funding and ecosystem support are needed.

We sat down for a virtual cup of coffee with Dr. Arnon Lavie, CEO and Founder of Enzyme by Design, and professor of biochemistry and molecular genetics at UIC, to discuss how early funding and mentorship impacted his company’s trajectory.

Dr. Arnon Lavie and Enzyme by design team members Dr. Amanda Schalk, Ying Su, and Dr. Hien Anh Nguyen | Photo credit: Jenny Fontaine – University of Illinois at Chicago. (Source: Illinois Ventures.)

Though he’s been listed as the winner in pitch competitions including MedCity INVEST and Chicago Biomedical Consortium’s Accelerator and Catalyst awards, Lavie’s success isn’t achieved alone. His team of top-tier scientists including Dr. Amanda Schalk, Dr. Hien Anh Nguyen, and Ying Su have worked not just on the science but also on building the business.

“I was very fortunate to have people that bought into the concept of a startup and did a lot of work,” he notes about his team. “There’s no doubt in my mind, the company would not be where it is today without them.”


Enzyme by Design is developing a form of asparaginase, commonly used to treat specific cancers, designed to overcome the toxicity associated with the drug. Dr. Lavie’s team has earned financial backing from Illinois Ventures’ Proof of Concept innovation funding, the Chicago Biomedical Consortium, and STTR/SBIR grants. In all, Enzyme by Design has garnered more than $1M in funding with an additional $2.5M on the near horizon.

Innovation funding supports University of Illinois at Chicago professors like Lavie with some of their earliest commercial translational funding. Since inception in 2012, the program has awarded $4.4M to 67 projects. These projects have gone on to receive $27.3M in private follow-on dollars, illustrating the catalyzing power of innovation funding. But beyond early investment, programs like this provide first-time founders with access to industry and finance leaders who can coach researchers in the process of taking their tech from lab to market.


Lavie is an expert in his field, but quickly realized that turning his research into a marketable product would require knowledge beyond the lab. Through various pitch opportunities and mentoring programs, he’s found expert advisors beyond his content area, ranging from business and operations, to manufacturing and marketing.

“The Proof of Concept mechanism was really helpful, not just for the money, but for meeting the panel evaluating the proposal. One of the things I learned was that I had to start reading the patent literature.”

Following some early guidance, he started voraciously reading available patents, reviewing colleagues’ grant proposals, and seeking opportunities to immerse himself in the language and thought processes of commercialization. From value proposition to market size, he realized that building a successful startup relied not just on good research or technology, but an understanding of where your work fits into the market. With assistance from Chicago Innovation Mentors (CIM), NSF, and NIH Innovation Corps (I-Corps), the team has gained a tremendous amount of data and knowledge, as well as access to mentors that helped shape and refine their future direction.

“Take away the scientific challenges – which are many – make an assumption that you can solve those. Now does it have legs from a commercial point of view? There’s a lot of bureaucracy that you have to understand. One of the biggest activation energy barriers for scientists is to understand that there’s a lot of leg work that they have to do just to set up the system and keep it operational.”


With a diverse set of advisors assembled, he looked for ecosystem peers and predecessors to provide a roadmap for the journey ahead.

“It’s easier to tackle a project after you’ve seen someone do it. We can go on this hike because we know there’s a path we can follow.”

In many ways, Illinois’ entrepreneurial ecosystem is thriving. Award-winning organizations such as iBIO, Chicago Innovation Mentors, MATTER, 1871, and mHub in Chicago; and Enterprise Works in Champaign provide educational opportunities and accelerator space. Universities like UIC, UIUC, Northwestern, and the University of Chicago provide a pipeline of research and some of the brightest innovators in the country. But the ecosystem faces a retention issue: as companies outgrow their spaces locally, they often move to the coasts. As a result, researchers and entrepreneurs like Lavie lose out on pieces of that roadmap to commercialization.

“There’s power in talking to groups that do similar things that you do. When I meet other biochemists, even though they’re working on other things, you can learn from them and help each other. I’d love to have more of that in the city.”

What’s needed for startups to thrive and, importantly, remain in Illinois? Researchers like Lavie and companies like Enzyme by Design need more affordable and well-equipped lab space, early funding, and mentoring to catalyze additional private investment. It will take a group effort of diverse researchers, industry partners, and funders to map out the future of Illinois’ innovation ecosystem.


Adapted (with modifications) from Illinois Ventures, published on July 29, 2020.


Arnon Lavie, UIC


June 20, 2019
Success Story
▸ Enzyme by Design featured in Crain’s!
Arnon Lavie, UIC, founder, president and CEO of Enzyme by Design, a biotech startup which received CBC support through a CBC Accelerator Award, interviewed by Crain’s Chicago Business

June 18, 2019
▸ The CBC-supported Enzyme by Design soars!
CBC Accelerator Award among grants that have contributed to almost $1 million in secured funding by a UIC spin-off company

June 4, 2019
▸ CBC Accelerator Award among Enzyme By Design enablers
CBC Accelerator Award winner and founder of the Pitch Perfect-winning startup Enzyme By Design, Arnon Lavie, UIC, explains what’s in the company pipeline and what challenges it may face

May 20, 2019
▸ CBC Accelerator Award helps Enzyme By Design win Pitch Perfect!
Arnon Lavie, UIC, founder of the Pitch Perfect-winning startup Enzyme By Design, acknowledges CBC as contributors to the company success

April 29, 2019
Success story
▸ Enzyme by Design Pitches Perfect!
Woohoo! A start-up led by a CBC Awardee Arnon Lavie, UIC — Enzyme by Design — wins the 2019’s MedCity INVEST Pitch Perfect Contest!

October 5, 2018
▸ Inaugural Accelerator Awards Announced!
1st Application Round (Spring 2018)

April 1, 2014
Success story
▸ High-Throughput Screen Promises to Combat C. difficile